Welcome to the Hall Lab
Starting August 2021 the Hall Lab is established at NC State University. Dr. Jonathan Hall is a new Assistant Professor in the Department of Biological Sciences. Dr. Hall joins NC State through the Chancellor’s Faculty Excellence Program cluster in Environmental Health Sciences. Dr. Hall is a member of the Center for Human Health and the Environment (CHHE), NCSU Toxicology Graduate Program, and the Genetics and Genomics Initiative (GGI) at NC State.
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The research in the Hall Lab involves the identification and characterization of genes/signaling pathways that are determinants of susceptibility to skin cancer. We are especially interested in how cells respond to environment stress including, solar UVB-induced DNA damage and tumor stress, to make decisions to live or trigger regulated cell death. These decisions and the ability to influence these regulated cell death decisions have important implications for tumor development and tumor regression. We are actively studying the role of the basic leucine zipper transcription factors, CCAAT/enhancer binding proteins (C/EBPs). Our laboratory’s current focus is to characterize the novel and critical roles for C/EBPB in regulating p53, the type 1 interferon response, and regulated cell death. To achieve our research goals we utilize molecular and cellular-based systems and powerful genetically engineered mouse models to define mechanisms by which these genes and signaling pathways determine susceptibility to skin cancer.